Zicam Sinus Relief Uses, Side Effects & Warnings (2024)

Generic name: oxymetazoline nasal [ox-ee-me-TAZ-oh-leen-NAY-sal]
Brand names: 12 Hour Nasal, 12 Hour Nasal Decongestant, Afrin, Afrin All Night NoDrip, Afrin Allergy Sinus, ... show all 34 brands
Drug class: Nasal antihistamines and decongestants

Medically reviewed by Drugs.com on Dec 21, 2023. Written by Cerner Multum.

What is Zicam Sinus Relief?

Oxymetazoline is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Zicam Sinus Relief (for the nose) is for temporary relief of nasal congestion (stuffy nose) caused by allergies or the common cold.

Zicam Sinus Relief may also be used for purposes not listed in this medication guide.

Zicam Sinus Relief side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Zicam Sinus Relief may cause serious side effects. Stop using Zicam Sinus Relief and call your doctor at once if you have:

  • ongoing or worsening symptoms;

  • severe burning or stinging in your nose after using the nasal spray;

  • chest pain, fast or uneven heart rate; or

  • severe headache, buzzing in your ears, anxiety, confusion, or feeling short of breath.

Common side effects of Zicam Sinus Relief may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Zicam Sinus Relief side effects (more detail)

Related/similar drugs

epinephrine topical, pseudoephedrine, sodium chloride nasal, Afrin, phenylephrine nasal

Warnings

Zicam Sinus Relief (for the nose) is used for temporary relief of nasal congestion caused by allergies or the common cold.

Stop using Zicam Sinus Relief and call your doctor at once if you have ongoing or worsening symptoms, or if you have severe burning or stinging in your nose after using the nasal spray

Before taking this medicine

You should not use Zicam Sinus Relief if you are allergic to it.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have other medical conditions, especially:

  • heart disease, high blood pressure, coronary artery disease;

  • diabetes;

  • a thyroid disorder; or

  • enlarged prostate or urination problems.

FDA pregnancy category C. It is not known whether Zicam Sinus Relief will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether oxymetazoline nasal passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I use Zicam Sinus Relief?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Using the medication too long or too often may worsen your symptoms or cause nasal congestion to clear up and come back.

Call your doctor if your symptoms do not improve after 3 days of treatment.

Do not share this medication with another person, even if they have the same symptoms you have. Sharing a nasal spray bottle can spread infection.

To use the nose drops (nasal solution):

  • Blow your nose gently. Tilt your head back as far as possible, or lie down and hang your head over the side of a bed. Hold the dropper over your nose and place the correct number of drops into your nose.

  • Sit up and bend your head slightly forward, then move it gently left and right. Stay seated with your head bent forward for a few minutes.

  • Avoid sneezing or blowing your nose for at least a few minutes after using the nose drops.

To use the nasal spray:

  • Blow your nose gently. Keep your head upright and insert the tip of bottle into one nostril. Press your other nostril closed with your finger. Breathe in quickly and gently spray the medicine into your nose. Then use the spray in your other nostril.

  • Do not blow your nose for at least a few minutes after using the nasal spray.

Do not use the nasal spray more than 2 times in 24 hours.

Wipe the tip of the spray bottle with a clean tissue but do not wash with water or soap.

Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.

Detailed Zicam Sinus Relief dosage information

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

Keep Zicam Sinus Relief out of the reach of children. Certain nasal medications can cause serious medical problems in a young child who accidentally sucks on or swallows medicine from the nasal spray bottle.

What should I avoid while using Zicam Sinus Relief?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect Zicam Sinus Relief?

Ask a doctor or pharmacist if it is safe for you to use Zicam Sinus Relief if you are also using any of the following drugs:

  • an antidepressant--amitriptyline, clomipramine, desipramine, doxepin, imipramine, nortriptyline;

  • ergot medicine--ergotamine, dihydroergotamine, ergonovine, methylergonovine; or

  • an MAO inhibitor--isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, tranylcypromine.

This list is not complete and other drugs may interact with Zicam Sinus Relief. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Zicam Sinus Relief drug interactions (more detail)

Popular FAQ

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More about Zicam Sinus Relief (oxymetazoline nasal)

  • Check interactions
  • Compare alternatives
  • Reviews (1)
  • Side effects
  • Dosage information
  • During pregnancy
  • Drug class: nasal antihistamines and decongestants
  • Breastfeeding
  • En español

Patient resources

Other brands

Afrin, Afrin Original, Zicam Extreme Congestion Relief, Afrin Sinus, ... +26 more

Professional resources

Other brands

Mucinex Sinus-Max Full Force

Related treatment guides

  • Nasal Congestion

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circ*mstances.

Medical Disclaimer

Copyright 1996-2024 Cerner Multum, Inc. Version: 7.01.

Zicam Sinus Relief Uses, Side Effects & Warnings (2024)
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